(verb) To randle. To randle something is to try and influence a turn of events in your favor, usually not very subtlely. To try and gain something that would most likely never have been yours.
"Damn brotha we out of concert tickets, there isn't a spot for you."
Randle No Can Handle means a person can't handle the amount of weed they smoked or the amount of alcohol they consumed. The symptoms of Randle No Can Handle is when a person throws up or knocks out cold.