An irrational or unjustified (and often uncontrollable) fear (and sometimes terror) of things that come in fours.
Rich: Did you hear about that new band?
Tim: no, I couldn't watch them, I had a disastrous outbreak of Quadrophobia.
Rich: Oh.
by Peregrin February 15, 2006
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The fear of Nvidia Quadro graphics cards.
"I can't buy that new graphics card, I have Quadrophobia!"
by cosmothefox May 5, 2021
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