Sarah: you saw the cute guy from school?
Jessie: yeah, we are friends... want me to p.u.o?
Sarah: YESSS!
by misslea.\ October 25, 2020
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Acronym for "Person of Unknown Origin." Refers to a person whose racial/ethnic background is not immediately obvious. Popularized by radio personality Howard Stern.
"I thought Angelina Jolie was Asian, then I found out her father is white. I guess she's a P.U.O."
by Dorothy May 8, 2005
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