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Mesopotamian Mud Spread 

The process of violently shitting your pants, pulling your pants down, then sitting on something/someone.
"Yeah dude, I heard he visited Margaret Thatcher's grave and gave it a good Mesopotamian Mud Spread."

Mesopotamian testicle tag

An ancient Mesopotamian game that involves a tagger chasing the other members of the game, when he gets near the members he will punch there testicle area as hard as they physically can, this happens until the tagger gives up or punches everyone’s balls. The female version of this is Mayan Cunt catching where it’s a girl hitting a vagina of other girls as hard as they can with the same rules
“Ok class today instead of doing basketball, we’re gonna play Mesopotamian testicle tag

Mesopotamian Bird Butting 

Mesopotamian Bird Butting, otherwise known as "Bird Butting" is a form of punishment, usually in friend groups, where everyone agrees to punish a person in the friend group by stripping them down to their underwear and covering them in honey, milk, oats, and birdseed, but not before tying them to a tree for a prolonged amount of time, to where birds will start to eat the covering off.
"Milo has been quite the nuisance recently, so me and the guys have decided to give him an old-fashioned Mesopotamian Bird Butting. Are you in?"

Mesopotamian honey bath

You have a sticky gang bang with honey it’s an ancient ritual. What goes back to 2335 BCE
Sargon of Akkad had many Mesopotamian honey baths

Prehistoric Mesopotamian Tablet

a cute name for your girlfriend that's older than you
thomas jefferson: hi prehistoric mesopotamian tablet

girl: kill yourself

messopotamia 

A play on words (created by one Jon Stewart) which serves on The Daily Show as a reoccuring update on the War in Iraq. The term originates from the word mesopotamia, an ancient region of Iraq. The area was the home of numerous early civilizations and declined in importance after Mongol invaders destroyed its extensive irrigation system.

Other variation: mess-o-potamia, mess o'potamia
Here is the latest report..on messopotamia.
messopotamia by Athena Kay September 28, 2004