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messopotamia 

A play on words (created by one Jon Stewart) which serves on The Daily Show as a reoccuring update on the War in Iraq. The term originates from the word mesopotamia, an ancient region of Iraq. The area was the home of numerous early civilizations and declined in importance after Mongol invaders destroyed its extensive irrigation system.

Other variation: mess-o-potamia, mess o'potamia
Here is the latest report..on messopotamia.
messopotamia by Athena Kay September 28, 2004
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Messopotamia 

john stewarts defination of the war in iraq... HE IS RIGHT EVEYONE, DOWN WITH BUSH DOWN WITH WAR!!
"and now we turn to the events in that great big land called messopotamia"-john stewart

Methopotamia

The part of Kentucky where the Ohio, Tennessee, and Mississippi Rivers converge.
In trying to make a Venn Diagram of amphetamine use, QAnon, and anti-vaxxers - the researchers identified modern Methopotamia, where shit gets recycled annually.
Methopotamia by JediSyd February 5, 2022

Mesopotamia 

from the Greek "meso" meaning "middle" or "between", and "potamos" meaning "river", Mesopotamia refers to the ancient land straddling the Tigris and Euphrates, currently more or less the site of a completely artificial nation called Iraq, which was cobbled together by the Frogs and the Limies in 1919 out of a few odd Ottoman provinces.

There's a lot of oil there, but no weapons of mass destruction.
The Neocons in DC want us to piss away all our national wealth in an ill advised adventure in Mesopotamia
Mesopotamia by succulentboi August 17, 2004

Mesopotamia 

1. Name of the ancient territory located between the Tigris and Euphrates Rivers from the Bronze Age to the Iron Age. Modern-day Iraq.

2. Where the band "The Mesopotamians" (Sargon, Hammurabi, Ashurbanipal, and Gilgamesh) ran out of gas while traveling in their Ecoline Van with only a single piece of gum, in the song "The Mesopotamians" by the real-life band "They Might Be Giants."
1. Teacher: You will have to do a 500 word report on ancient Mesopotamia.
Student: Awww....

2. "The Mesopotamish sun is beating down
And making cracks in the ground
But there's nowhere else to stand
In Mesopotamia (No one's ever seen us)
The kingdom where we secretly reign (And no one's ever heard of our band)
The land where we invisibly rule"
-Lyrics from "The Mesopotamians" by "They Might Be Giants".
Mesopotamia by JordACE July 6, 2009

Mexopotamia 

The land mass of Mexico, Central and South America, and Spain, which some believe may have existed during the Paleolithic age.
"Yo, where was your boy Carlos from?"-Freddie
"Oh I don't know, one of those countries in Mexopotamia"-Bigoted White Girl
Mexopotamia by Pterodactyl April 28, 2007

cookierun_mesopotamia 

person 1: hey have you heard of cookierun_mesopotamia?
person 2: yes im mutuals with them they r cool