Top Definition
The act of getting your brains fucked out, through your ass.
Guy 1: Hey, you know that Cheryl chick?
Guy 2: Yeah, I hear she's into Anal.
Guy 1: Hell yeah, I hooked up with her last night and gave her a total Losodomy! I had her walking funny and mumbling incoherently all night!
by Kuhnaydeein April 14, 2010
2 Words related to Losodomy

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