Top Definition
GNO
G-irls
N-ight
O-ut

When girls get together to go out and have fun
"My man and I broke up...lets have a GNO!!"
by Alchiwhore4life December 11, 2004

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GNO
Girls Night Out! When girls hang out and have a great time. You go for dinner, watch movies, talk about people, play games, and stay up all night. It is so much fun!
OMG A,L,M,J and E are having a GNO today!

I wish i was going!
by BlondeChick July 21, 2005

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Deliberate misspelling for no. usually in all capitals.
Oh GNOES TEH GOATSE ATTACK!!!1
by glo December 11, 2003

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GNO
Acronym for "Gays Night Out."
Danny: "Guys, tonight's GNO is dinner at Fridays. Don't call the women."
by DJ Andre October 15, 2009

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This is a night out for the girls. Once every week or two the girls go out together to party it up. Married, single, gay, straight, stoner, lush...all are welcome.
Last G.N.O. was crazy. This guy insulted my friend so she poured two glasses of water over his head. HA! Don't mess with my bitches!!!
by Niva June 08, 2007

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GNO
Gays Night Out
Guy 1: Look boys, we don't need no women. Let's have a GNO!

Guy 2: Right on boyfriend, let's go shopping!
by manly man92 May 28, 2009

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GNO
G- Get
N- Nob
O- Out

Thus literally meaning get your nob out
Usually used as an insult or as an obvious sex phrase
Boy: You're a loner and you've got no friends (Insulting)
Boy2:GNO

Or

Boy: Wanna have sex?
Girl: GNO!
by The Pro One March 11, 2009

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