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A term commonly used by our grandparents/ aunties and uncles that refers to the bathroom. It is a nice way for old people to politely make things awkward and let you know they have to go take a dump. Often say it in public places like Sears or the food court at the mall.

Biffie is often mistaken for some sort of cute way of saying BFF's and Besties but it actually makes you think of grandma grunting one out in the Smitty's washroom."
"Keep your eyes out for the washroom kiddo, Grandma had McDonald's for lunch and it always makes her have to go to the biffie."
by TimTimTimTim March 27, 2013
4 0
Biffie is used as a term of endearment for a best friend whom you have been friends with FOREVER & will continue to be friends NO MATTER WHAT! Through thick & thin..Biffie's have been through it all!

it's you and me together forever and never apart, maybe in distance, but never in heart. =)
Deana & Kelly prime example of Biffie
by The Biffie =) October 11, 2011
7 20