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The cornerstone piece of the unholy lego empire.
Hand me that red 2 by 4 piece over there.
2 by 4 by Flick Montana August 31, 2006
Also known as a 4-by-4 (or any multiple of 2). Describes someone with an abnormally large ass.
"She's got a 2-by-2 on her, don't she?"
"I gotsh me a 4-by-4"
2-by-2 by Cowboy Chick February 7, 2014
The art of performing sexual intercourse on a 4 legged animal, via the butt hole.
Call a "2 by 4" because a human has 2 legs, where as animals have 4
"Dude, Mark totally performed a successful 2 by 4 on Jamie's dog last night"
2 by 4 by MMjr April 21, 2008

2 by 4 pretty 

a term used to describe a very ugly person usually a female. implying that they look as if hit way hard in the face with a 2x4
"man I had ta bounce out early, that chick was 2 by 4 pretty"
2 by 4 pretty by DeMonToyZ June 4, 2014
twenty four ounce can of beer
I went to the store and asked the person behind the counter for a meal pack and she gave me a 2 by 4 and a BC Powder.(for the buzz)
2 by 4 by Ben March 24, 2005
Nickname for people with their eyes really far apart. You can put a 2 by 4 between their eyes and they can still see.
Hey! Check out 2 by 4 over there!
2 by 4 by MeanGuy May 15, 2006