Basicly 22s are some hot rims that are 22 inches
Oh! Dats a clean ride wit dem 22 inch spinners. Go head pimp! Yoouu Knooow!!
by Ebony January 28, 2004
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1) A .22 caliber handgun
2) Any rim that measures 22 inches in size
3) Slang term used for women to let you know they are prostitutes.

1) Don't tote no 22's
2) Magnum cost me 22, sat it on them 22's
3) Lil mama super thick, she say she 22

(All examples from Rick Ross' Hustlin)
by TheChef May 1, 2006
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At a bar, two men watch as a hot, librarian walks into view. One man looks at the other and says..."check out the 22."
by jjpaige July 12, 2009
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A sexual position depicted through numbers (like 69); meaning doggystyle (could be used for anal sex as well).
by SoLux July 20, 2008
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the act of having sex.

Sex was seen as entry #22 of a list on relationship building strategies. Many wondered why it was not #1.

Alone is 11.

twice is 44.

44 has also been used to mention the act of 22 with 4 or more consenting adults.
Hey honey, let's put the kids to bed and go have some 22.

This party is getting dull, let's slip away into a dark corner for some 22.

Do you want to see if that couple over there wants to 44?
by mightyacorn January 14, 2010
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Not only do they refer to rims, but also the size of someones arms: usually the Biceps.
by s1yfoxx September 14, 2010
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The number seen often that symbolizes best friends. When seeing a 22 on random objects or at random times, you should stop and inform your best friend that you are thinking of them.
Best Friend #1: Orders Starbucks and the bill totals $4.22
Best Friend #2: Received a picture on their cell phone of the bill and thinks "Ohhhh, my best friend is thinking of me"
by pmahc1mik August 3, 2010
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