1) A .22 caliber handgun
2) Any rim that measures 22 inches in size
3) Slang term used for women to let you know they are prostitutes.
1) Don't tote no 22's
2) Magnum cost me 22, sat it on them 22's
3) Lil mama super thick, she say she 22
(All examples from Rick Ross' Hustlin)
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