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It has two meanings, 'Sure' and 'Shit'. It all depends on the way you say it.
Sure - 'Fo Shizzle' = For Sure, Definately

Shit - 'That's The Shizzle' = That is good.
Shit, but for retards
Mark: Oh Shizzle! I got the question wrong! ):
Person 2: Shut the fuck up mark your iq is below 30 you fucking stupid ass rat.
Mark: ):
Shizzle by DisBoiEpic January 18, 2022
the most annoyingly over-fucking-used word EVER
shizzle by ThisBirdHasFlown April 13, 2005
In response to a yes or no question, can be used as "Fo' shizzle", meaning "For sure."
Shizzle by Giarc December 20, 2003
Shizzle=Sure
Its just when u take the last part off of the end of the word and replace it with izzle.
Shizzle by Little white girL September 30, 2003
a word which is funny to say when you get bored, you can randomly say shizzle, and then if the person you're talking to has any brain cells they will say on da hizzle or something completely pointless and stupid like that, it is weird and lame but it fills up hours (it works best if black people say it, i don't know why) and then when you get sick of this pointless crap you can say bizzle which sounds a bit like bye or gizzle (going) or gizzle fizzled nizzle (get fucked noob)etc etc
me:fo shizzle
dude: on da hizzle
me: zizzle
dude: frizzle mizzle
(four hours of pointless moronic izzle noises ensue)
me: gizzle fizzled whizzle
dude: bizzle
me: (unable to bear it any longer)SHUT UP!!!!!!!!!!
shizzle by Moominbaybee May 29, 2008