tweak 

adjust a small amount for improvement as in a race car or computer settings

I entered my computer bios and tweaked the memory settings.

My car is oversteering, I will tweak my camber settings.

tweak by earl February 13, 2005

tweak 

(1) to act like a spaz (see spaz) (2)to be incredibly hyperactive to the point that people believe you to either be mentally insane or hopped up on something (while not under the influence of drugs)

Did you see how Doug was tweakin' the other day?

tweak by JK April 3, 2005

Tweak 

a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme intoxication. Users were left alone when they "tweak," or are "tweaking out" until the initial strong effects of the drug wore off a little and they were more coherent.

The term has come to loosely refer to being high on speed, as well as unfortunately children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.

You might act a little crazy when you tweak, but you'll come down in a minute or two.

Tweak by Lady Artemis April 3, 2010

tweak 

1. a person who is tweakin out from crack
2. a crack baby

omg shes tweakin!!

tweak by Krysti Moaner April 11, 2003

Tweak 

Street name for vitamin b6. AKA hack/beesicks. Commonly used for assisting the consumer in having a lucid dream.

Jordan hooked me up with some tweak, it was dope.

Tweak by Michael November 22, 2004

Tweak 

People that love to have sex. Someone whose always horny.

YO I HEARD SHAWTY RITE DERE A TWEAK!

Tweak by robbyfhark July 29, 2010

tweak 

to fucking snap! to feel like you have been through enough bull shit and you just want to hurt someone

my girlfriend was putting me through so much shit last night i was ready to fucking tweak

tweak by Kevin Bowen September 24, 2007