1. To fail at something, to do something wrong/incorrectly (sometimes repeatedly). Someone that screws up a lot is called a "screw-up"

2. To describe hurting someone emotionally or physically. Commonly used when threatening the one you want to hurt.
1.
Person 1: "I stayed up late last night to study but I couldn't concentrate that well."
Person 2: "You're gonna screw up that test."

"This is the 5th time in a row I'm getting a bad grade. I'm really screwing up."

"I couldn't stop stuttering when introducing myself to him. I screwed up so badly."

2.
"Oh yeah!? You wanna mess with me, kid!? Ohh, I'm gonna SCREW YOU UP!"

Person 1: "Haha, I totally screwed that kid up, did you see his black eye?"
Person 2: "Yeah, he deserved it!"
by HaltDenMund December 20, 2010
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The act of failure in doing a job which wasn't intended or expected by the others.
Jim:What the fuck was that man?
Robert:I know I screw up.
Jim:*angry and disappointed*
by dipshite March 29, 2014
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A person who does or says something so dumb and screws up friendships
by Shit friend July 2, 2017
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Screw up is when you say the wrong name to your bitch while having sex.
uhhh Britney spears, you're so hot - SLAP - My name is Celine dion you stupid motherfucker!
by Kasper Nielsen April 3, 2004
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Screw up can be two different things
Ugh I’m such a screw up. :=(
Dang it I just screw up

Although your not so don’t ever say that or else... I’ll call you a turd on repeat!
by Roseachild:/ April 25, 2020
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A group of Houston Rappers who all collabarated with D J Screw.
Lil' Keke, Lil' Flip, Hawk etc
by C Lo January 25, 2004
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Rap Group Made By DJ Screw From Screwston TX (Not All Are From Houston Or TX)(R.I.P.) SUC/SU4C :Soldiers United 4 Cash - Lil Keke H.A.W.K. (R.I.P.) Fat Pat (R.I.P.) Z-Ro Big Mello (R.I.P.) Big Moe (R.I.P.) Lil Flip C-Note BG Duke Will Lean Lil C Mike D Lil O ESG Point Blank Gator Mafio Big Pokey Big Jut Lil Troy Lil Boo (R.I.P.) Dave LOS Lil Randy Corry Blount K.K. Shawty Mac Lil Chuck Al D Youngsta & Grace Affiliates - Trae & A.B.N. (Lil Boss Jay-Ton Lil B Dub G) Dougie D Trey D Shepdog UGK.....
The SUC iz 1 of tha thoedist in da south! SCREWED UP CLICK FO LIFE.
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