To adjust or fine tune things, to personalise an object and make it better to suit one's liking
Holly was eager to tweak her sister's white canvas slip-ons with rainbow unicorns because she knew they were her sister's favourite mythical creatures.
by fln September 23, 2013
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1. Jonesing.
2. Completely disoriented.
"Gurl....I'm so tweaked I can't even see straight."
by Peter Tweaker August 6, 2003
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She's been ragging on me all morning. I wonder wahr she's so tweaked about.
by Malkim El-Shabazz September 24, 2003
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1. Become influenced by drugs or Foreign substances...in a bad way

2. IT. To say you fixed something on a PC or Server when you really broke it, and really broke it goood.
1. maaaan... I'm so tweaked out, I vomited all over myself while driving on the Motrway

2. IT. Tim Black the ginga...grrr
by Bob is u're auntie August 23, 2008
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An idea that just appeared. When your mind brings a solution to something into your thoughts.
In a conversation with someone you are trying to pick out a solution to a maths sequence and suddenly your brain recoginses the pattern........you tweaked to the idea being used.
by Mr Berry, Moon March 14, 2012
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he tweaked his wrist when he fell off his bike
by Gordo352 April 4, 2006
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