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Portmanteau of the now not often heard 'twee' (describing something excessively quaint or cutesy) and 'weird'. Thus meaning something so twee as to become uncomfortable or weird.
Man: I've heard that Susan in accounts is obsessed with Sylvanian Families and spends all evening making clothes for them and talking to them and stuff.

Woman: Aaah what? Man that's tweeird!
Tweeird by RemainsAnomynous October 28, 2009
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Someone under the influence/ high on meth who looks or is acting weird or strange in behavior(s).
Look here tweerdo, you're creeping me out. Sit your ass down over there and don't move.

Look over there, she looks like a tweerdo. Typical in the Independence walmart aisles.
tweerdo by SavagebeautyTK November 25, 2018
Related Words
A crude conjunction of the words "totally wierd"
Missy likes to lick the bleachers-that's tweerd!
tweerd by lizspittle April 10, 2007
A Twitter user who follows someone without any readily apparent reason.
@tweirdo1 Hi. Who are you? Why are you following me? I just made my Twitter account SECONDS ago.

@twierdo2 Hi. You're the second person who wants to follow me without knowing who I am. I have dubbed you both "Tweirdos."
Tweirdo by Ancient Weirdo July 23, 2012
Tired, Wired and Weird. Usually a state of being after a significant period of partying.
We are going to be hella tweird after this weekend.
Tweird by myco2012 October 8, 2011
something that is tite and weird
Damn dawg, that shit is tweird!
tweird by liljayhawkboyy May 19, 2008
Too weird
You're tweird.
Tweird by Fullsaile February 21, 2017