a person who has been awake,on average,for about 2 weeks without sleeping because they've been abusing speedy drugs(usually,but not limited to:crystal methamphetamine)
this tweaker told me the only cure for coming down is more drugs.
by insanegerbil November 23, 2003
Get the tweaker mug.
a person who is addicted to meth...(drug)
that guy smoking that shit on the chair over their is a tweaker!
by lindsey_57 July 24, 2006
Get the tweaker mug.
A 'speed'/'crystalmeth' freak.
Tweaker's are 'tripped out' addicts who live for 'gas'/'ice' and party for days with no concept of time or the outside world.
"Val Kilmer play's his best role ever as a hardcore tweaker, a crystalmeth freak, in a great movie called 'The Salton Sea'."
by Diego August 18, 2003
Get the tweaker mug.
someone who abuses methamphatamine.

usually skinny because they dont eat.
dark circles under their eyes because they dont sleep.
can harldy stand because most of their blood viens have collpased from constant injecting,

they transform themselves into a hermit-like state and keep to themselves while trying to have a normal life.
kid 1: i think that jon is using meth.
Kid2: yeah i definatly think he is a tweaker
by lovebabefor April 9, 2009
Get the tweaker mug.
1) A speed, or meth addict who has assumed the role of the drug, in other words, they lost their personality to the drug.
2) An ex- deadhead or hippie who has fried their brain and is now living in the small, paranoid world of warped memories of a mundane adolescence. They communicate by spreading urban legends as "amazing" inspirational stories that align with their perception of reality.
3) A stupid, spastic teen (or adult, but less common) that display ignorance and naivety with every action.
I was walking through the Haight the other day and was surrounded by tweakers.

I went to my high school reunion and the tweakers were still messed up in the head.
by stv October 6, 2004
Get the tweaker mug.
basically an hore or slut a female who has sex with many guys
yo you know dat girl down da street?

yea man she a whole tweaker
by dabullty December 9, 2009
Get the tweaker mug.
one who 'tweaks balls' as in one who uses the drug methamphetamine to get amped and then shakes around and talks non-stop.
I would have asked Mary to help me study for my test but she's such a tweaker --she couldn't sit still for more than 2 minutes so that's why I got a D+
by brandon December 4, 2002
Get the tweaker mug.