Top Definition
Just generally trippin', tweakin', weird, actin' a fool, blackin' out, goin' off. Not necessarily due to drugs, though that's the obvious reference.
Homie was on one, just buggin' like I shot his mom or something.
by Kuahmel January 22, 2009

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To be fucked up on whatever your drug of choice is. It is beyond just tipsy or lightheaded, it's full on faded/twisted/tweaked/trippin/high/etc.
Damn, Rick James was on one back in the 80's.

That bum jackin off in the corner must be on one, damn tweak.
by Joe Blaze January 25, 2008

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to be under the influence of methamphetamines
i heard joe's been on one for the past three days
by Leya Fish January 19, 2003

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Feeling way too good.
Just broke up with my girl and this alone time has me feelin' on one right now.
by Fresh Livin' May 06, 2015

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To be under the influence of methamphetamines AKA ice,meth,speed,dope,etc.
Tuttie's on one man, he been smokin' ice all week!
by rooster760 February 28, 2005

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Mass consumption of alcohol/drugs. Going past the point of no return and coming back only to return again.
You might have been one one if:
Its 9am and you are lying naked in bed next to a 300 lb. Miami, who you have never met before, with a peculiar taste in your mouth.
You wake up in the drunk tank and you have been told you’re being booked for defecting on top of car in a shopping center parking lot in broad day light.
Kid 1 "I have never seen that kid sober"
Kid 2 "He is ALWAYS on one"
by oneder April 30, 2005

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Soft and offensive. Just like you.

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to be high, faded, to have just smoked weed.
My man James was on one at the party.
by metalgearray February 20, 2005

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The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

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The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

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