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a combination of the words "twack" and "acne". its the acne you get from being twacked out for too long and usually not taking care of yourself.
person 1: "dude, how long has chris been tweaking?!"
person 2: "idk but he's been on one for a while..."
person 1: "I can tell, he's got twacne and hasn't showered in days!"
twacne by divine sally March 4, 2010
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when a female has acne on her twat
Yo Man, That hoes got mad twacne!!!
twacne by Kevin McNally June 4, 2008
Related Words
The feeling one has when one has been awake for to long on a variety of substances, primarily ecstasy, cocaine, and/or crystal meth.
Dude I took my last E pill five hours ago and now I'm just straight twackered.
Twackered by Rellik Uzi August 14, 2010

Twackerjack 

A sleep deprivated person that is spun out on meth.
Twackerjacks are easily detected by their severe body and facial contortions (see: Monkeyface).
Damn girl! You are completely twackerjacked. Go to bed.
Twackerjack by lledrovc July 25, 2007

Double Twacker Half 

A 30-pack of beer:

Twacker = 12
Double Twacker = 24
Half Twacker (Half) = 6

Double Twacker Half = 30
I picked up a double twacker half from the beer distributor.
Double Twacker Half by Pakalypse January 22, 2011

twacked out 

when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
twacked out by The KKK December 21, 2004
Lily bell
Lily is a the definition of twacker
Twacker by Niggerboi69 June 25, 2019