After breaking his sobriety and drinking, Amy told John to tighten it up.
by SLAP May 11, 2004
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If one is 'uncool', a cool person said, "let's do something cool" and said 'uncool person' agrees does do the cool thing he/she has "Tightened Shit Up"...
To apply liquid nitrogen to the anus prior to penetration through a gentle vapour gas expulsion with no more than twenty PSI thrust from machine of choice.
To apply polyethylene 1 1/8 clamps to each side of a vagina and penetrate with a 1 5/8 dildo, 10 inches in length... (Not healthy or recommended)
1: Footy G asked Ryan if he wanted to hit a cashier, drink some Tequila and beat up a midget. Ryan agreed; and he "tightened shit up".

2. I "tightened that shit up" on that chicks backdoor. Now the chemical sign for Nitrogen is still Ni, however now it means "Not Inside!!!"

3. My clamps barely held her meat curtains so I had to "tighten shit up" with booster cables.
by r2says February 19, 2014
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Prison slang for "pay attention". Can also be used to tell another inmate to stop goofing off.
"Yo man tighten up! Don't you see what's about to happen?"
by graybar hotel February 9, 2014
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1. To get your act together. 2. Don't be so loose
Mary: Sarah you should put your clothes on!
Kelly: Yea, Sarah tighten up!
Sarah: Mary you should stop takin it deep!
Kelly: Yea, Mary tighten up!
by Joe11 June 28, 2006
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To calm down / loosen up. Typically used when someone is overreacting or in general not being chill.
2. Mike: Tighten up cuz, ain't nobody pulled on yo weave.
by hastyboomalert July 11, 2012
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a command from one hallion to the next to brighten him/herself -
Well dog, whats the craic?
Feck all, just dyin here!
Rough nite last nite then?
Aye, it was raw!!!
Quit your cryin and tighten up!!
by patjoe September 27, 2012
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A state of altered consciousness induced by narcotics. Most commonly marijuana.
Michael had a Service Huddle with his friends until he got tightened-up.
by Big Mike D. January 29, 2005
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