1930's expression for "fuck" (vulgar) or "see" (polite). You hear this expression in old movies, or recent movies (like Get Low) which is about the 1930's.
In the old days we'd say, "When did you take up with Sallie Mae?-- after all she's a married woman." Today we would say, "When did you start seeing Sallie Mae?" Or, "When did you start fucking Sallie Mae?"
by Gabinox October 26, 2011
Get the take up with mug.A phrase you can inject in a conversation after someone begins to complain or go on about something that you are not interested in.
by General America December 19, 2010
Get the Take it up with my butt because that's the only one that gives a crap mug.