1. A man who behaves in an overly familiar way and is always replying to the social media messages of a woman he doesn't know or is barely acquainted with.

2. An annoying man who replies to social media messages, in general - whether this annoyance is due to a perceived know-it-all attitude, excessive familiarity, banal arguments that the annoyed user doesn't feel compelled to reply to again and again, or violation of some imagined pecking order.
Mental health improves 120% when reply guys are blocked or muted
by Esther Lolstein December 20, 2018
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A detractor that replies and leaves hate comments on every single social media post or video. This type of troll is dedicated, spending hours every single day leaving negative comments.
One of my reply guys posted another hate comment on my YouTube video. He posts negative things on every single YouTube video and Twitter post I make, every single day. What a sad life!
by SamSteck June 18, 2022
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A guy that replies.
Oh look that reply guy is replying to all the comments.
by Nezahualcoyotl December 23, 2018
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The greatest man on earth that is employed at Applebee's. He talks to fans of Applebee's on the facebook page.
Your lord and savior.
Have you accepted Applebee's Reply Guy as your lord and savior?
by LCFlygon July 28, 2012
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