A person who has taken and abused drugs for so long that they achieve a permanent state of "highness" whether they are on drugs or not. They are literally a little bit "munted" forever...
by TinkaBell January 9, 2017
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To have taken so many drugs your brain is irreversably fried
John Saunders went way too hard for way too long but hasnt touched drugs in 10 years. Even after such a long period of sobriety he shows signs of serious brain damage and as such is permafried
by rocketdogz September 21, 2010
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A person who has taken and abused drugs for so long that they achieve a permanent state of "highness" whether they are on drugs or not. They are literally a little bit "munted" forever...
by TinkaBell January 9, 2017
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a person who has smoked so much weed that they are now pemanently fried
she smoked so much weed that now she is a permafry
by XxbertxX September 1, 2006
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Getting baked too often to where you have the effects without smoking, makes you feel stupid and lost at times
Me and my bro smoked for 10 days stright we are permafried
by Ace-_-420 August 5, 2011
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When youve done too many drugs in a short amount of time youre permanently fucked up/ retarded

Also known as a Matthew Ramo.
"Dont be a matt ramo, wait a couple weeks before you trip again or you'll be permafried."
by Fanxis August 15, 2017
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