Restarting a video game or video gamelevel after one mistake because the mistake meant it was no longer possible for you to achieve your goal on that attempt.
I must have committed perfecticide a thousand times before setting my new high score in Mario.
The unnecessary and excessive over development of a product, process, or statement through the unending cycle of low to no value added refinement.
Elmer, you've gone too far with this project, no need to perfectivize this one, we're not looking for Miss Right here, we're looking for Miss Right now.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.