pep-up Share definition Flag A smoothy containing bananas, wheat germ, brewer's yeast, molasses, and yogurt that was popularized in the Seattle area during the 1970s. My father concocts his morning pep-up each day before yoga class. pep-up by ClamOrPotato July 1, 2016 0 0 Get merch Get the pep-up mug. Buy Now — $32.95 See more merch