1. A flap of loose skin and/or fat that hangs from the waist, usually due to obesity, though pregnancy and/or repeated weight gain and loss can make the condition worse.

2. A metaphor for anything that impedes movement or performance.
1. Fred hasn't seen his dick in years due to his panniculus.

2. Our economy is sluggish due to the panniculus of foreign debt.
by mirishka999 August 25, 2010
As result of being super fat someones' stomach hangs anywhere from their genitals to their ankles. Grade 1 is the smallest - Grade 5 can be dragging on the floor.
Trisha is morbidly obese and has a panniculus down to her knees!
by mindtriplx December 11, 2007