This is a term usually reserved for situations where the only solution for avoiding an untimely death is to run for the hills. While this term is sometimes seen in lower case, it is always screamed at the top of ones lungs, usually right before the person behind them is killed/maimed/turned into a newt.
"OMG, is that Manbearpig?"
"OHFUCKRUNWEREGONNADIE!!!"
An extreme from of obfuscate. This is usually a feeling that a haxor gets when code cannot be reverse engineered into somethingunderstandable due to some extent of obfuscation that was applied to the code at compile time.
I'm gonna obfucksfrustrate my code making sure that any mofo haxor that breaks into my boxen and tries to steal my binary for decompilation will get fucks frustrated by it.