When a person is unavailable, often because they are too busy, injured, or taken. Can also refer to objects that are broken and not yet fixed.
Harry won't be able to make my party; he says he's out of commission for the next couple of months due to work.

Dang it, I caught an STI. I guess I'm out of commission until I finish my course of antibiotics.

Ned's car is out of commission until he saves up enough money to fix it.
by floopedia December 19, 2022
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When you have sex with Dean Lonergan and his surprisingly large penis
Person A "Ah man, I was put out of commission"
Person b "oh, you had sex with Dean Lonergan as well?
by FishFucker_69 March 13, 2023
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