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Casual Japanese noun meaning Older Sister. Onee-san is the formal form of this noun.

Onee and Onii (Older Brother) do not have to have the ending -san, -kun, -chan, or -sama
See Nii-San; Onii-san; Ototo-kun; Imoto-chan
Nee-san, when are we going to the mall?

姉、私たちがいつモール街に行きます

Onee-san, watashitachi gaitsu mo^ru machi ni iki masu?
Nee-san by Khana Hatake January 1, 2010
Related Words
Nee-San (Pronunciation-Nè Sa)

Meaning-Big Sister

Also:-Nee Chan is generally regarded formal for Elder sister.
Nee-San by AlXN January 28, 2017

Bitchy née san 

you’re cringey and a dumb anime fan. So if you’re a dumb anime fan, I will call you Bitchy née San. If you’re a smart anime fan, Ill call you a cool anime fan.