According to my Spanish book, it means "Jeez!". It's more like a general expression of surprise, annoyance or exasperation.
"Hijole! Why did that puta even bother calling him?"
by Lolita Alvarezz May 2, 2006
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"Son of a..."
It's a shortened version of hijo de puta (“son of a bitch”).
Glottis: We have to find the key!
Manny: Hijole!
by Master Speed November 3, 2016
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