The state of possessing either a malfunctioning set of testicular apparatus or no testicular apparatus. This state of being is most common in canines, cats and whipped married men. The origin from the word stems from the distinction between one with a pair of testicular apparatus and one without said apparatus. The one with the apparatus can let nature continue whereas the one without the apparatus can't let nature continue, hence DE-NATURED.
My dog is now denatured as his testicles were duly ripped from his ballsack yesterday at the vet.

A: That man is being pushed around by his wife. He must be denatured.
B: Explains why they don't have kids.
by zk3x June 8, 2010
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To bring a bitch to orgasm with salt, acid, heat, and agitation
Linda and i Denature the protein, that bitch was fat-free when i was done with her
by wafferthinmint October 26, 2016
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A state of change, usually physical, almost always in a negative way.
'Hey, have you seen what Joan looks like lately?'
'No, but I heard she's completely denatured since our last encounter'
by BarryFromWigan August 27, 2021
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The process of breaking down proteins due to extreme or unfitting conditions of its environment. This may be due to a damaging level of PH or temperature of the proteins surroundings.
Denaturation killed the communist enzyme.
Oh no, I'm denaturing! Said the protein.
by Not George Washington the 3:d December 10, 2018
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