To be on cruise control means you are detached from the world: you glide through, paying limited or no attention to events which occur around you. You often stare into space. You may daydream, but most of the time you aren't really thinking about anything. You may feel lost even in familiar surroundings.
This can result from the break-up of a relationship, trouble within the family or the death of someone close to you.
It may involve drug use.

The term derives from the cruise control system on a car, which allows a specific speed to be set and regulated automatically by an onboard computer; the driver does not have to use the accelerator pedal

Caps Lock is cruise control for cool.

When you run down the street while pissing on the wall/fence.

The vaginal, anal, and oral penetration of a woman while she is jacking off two men. All of the 5 men penetrate their assigned orifice for 6 minutes, and then switch off. The total time for the activity is 30 minutes. Cruise Control is mainly intended to humiliate the woman in question

Receiving a blowjob or handjob from the passenger while driving the vehicle.
(Pun meaning the driver is "cruising" in the car, while the passenger is "controlling" the driver's penis)

The state of which your body has exhausted all its energy during sexual activity and results in a slow, uncontrolled motion that oddly resembles a humping motion.