Meaning you have an extra set of chromosomes. Nice way of calling someone a retard. Powerplay is a man-up scenario in sports, mostly from opposing team serving a penalty.
Person 1: "Wow, that guy is a moron."
Person 2: "Yeah, they must have a chromosome powerplay going on."
Person 2: "Yeah, they must have a chromosome powerplay going on."
by M_Dubz152 June 7, 2023