by j00j00 May 28, 2015
Used to ask an indiviudal how things are going. Can be responded to in urban settings by using the word Chillin or in Jamaica by saying Cool
by ICO777 August 12, 2009
Used to mean "she/he/you is/are very attractive and I would very much enjoy making love to you." It is derived from "A Night at the Roxbury"
Steve: What's up? What's up? What's up? What's up? What's up?
Doug: Steve, slow down.
Steve: I can't help it man, it's hottie overload.
Doug: Just pace yourself.
Steve: Ok... What's up?... 2, 3, 4. What's up?... 2, 3, 4...
Doug: Steve, slow down.
Steve: I can't help it man, it's hottie overload.
Doug: Just pace yourself.
Steve: Ok... What's up?... 2, 3, 4. What's up?... 2, 3, 4...
by Tonberry2000 April 22, 2009
Boy: Ayo, Whats up with the whats up?
Girl: Fuck outta here, I got a man. No Single Ladies shit.
Boy: ....Fraud.
Girl: Fuck outta here, I got a man. No Single Ladies shit.
Boy: ....Fraud.
by Ctfu February 10, 2010
A phrase used to ask about something odd, or what the point of something is. The word "that" can also be replaced with whatever noun the person is asking about. It is also common to inerject the word "fuck" into the phrase to express shock or discust.
What's up with the smirk?
Look at all those bags on the road. What's up with that?
Person1: What the fuck's up with your hand!?
Person2: Ahh! Why are you just standing there?! Take me to the fucking hospital!
Look at all those bags on the road. What's up with that?
Person1: What the fuck's up with your hand!?
Person2: Ahh! Why are you just standing there?! Take me to the fucking hospital!
by Cinymin86 November 16, 2009
Meaning that you fully understand and/or agree and find yourself excited about the idea or suggestion proposed.
Friend 1: "Yeah so I'm thinking we chill before, and then hit the club by 9. Got mad beer at the crib anyway"
Friend 2: "That's what's up"
Friend 2: "That's what's up"
by KelsBels April 06, 2008