Serio Syndrome 

To have every sexually transmitted disease at once. It thus neutralizes the infected from the affects of the various diseases. However, whoever they have sex with will die instantly.

Jeff has Serio Syndrome. He fucked Deb last night and she immediately died.

Serio Syndrome by Ridwiz October 24, 2012

Sergio's dick 

It is not real

Sergio's dick is like Santa Claus, not real

Sergio's dick by heflihk October 25, 2016

Serio 

One of the best Chicano Rap Artists from the Westcoast.

He is one serio vato. Serio is one of the best chicano rappers I know. Nightmares Turned Into Reality from Califas 2 Washifas

Serio by Jonathan Perez January 10, 2008

Serio 10 

n. I swear to god times 100

i like that girl serio 10

Serio 10 by dylannnnntizzzzzy September 30, 2018

serio 

spanish for serious

boy: Quiero los zapatos azules.

girl: serio?!?!?!?!?

serio by 662614 September 26, 2009

Serio Pedo 

Literal translation "serious fart"
It's equivalent in English is "real shit"

Serio Pedo, you don't have no salsa, but you're serving tacos? or
My car just broke down dude, serio pedo.

Serio Pedo by Cheymez May 24, 2017

serio 

Means the same as "serious"

"Are you serious?" becomes "Serio?"

serio by Starry December 8, 2004