One of the most basic terms in ebonics, this is essential to know. The word bitch is not necessarily derogatory in this case. Usually used to coax a laugh out of one's homies.
See Jane run. Run, bitch, run (for your life)!
~Sinfest
by Matthias Drake May 22, 2006
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Originates from the interview scene with fictional character Shorty Meeks in Scary Movie.

In the era of internet memes, this is sometimes used in:

1. Video game footages, where you have no chance versus the approaching opponent or vice versa.

2. Any movie or video game scene, where a character attempts to bail (run for his life).
Shorty: I'm on T.V. Oh shit, first "Cops" now this. I'm gonna be a star, son!

Gail Hailstorm (Reporter): So how close were you to the victim?

Shorty: Oh real close. Right 'til the roofies wore and she woke up. Then she was all talkin' 'bout pressing charges so I just pulled my tongue outta her ass and left.

Gail Hailstorm (Reporter): If you could have spoken to her before she died, what would your last words to her have been?

Shorty: Run bitch run!
by BlazinItSince420AD November 24, 2015
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