When first created was used to describe a fictional disease, when pee comes out your eyes and poop comes out your mouth. The word is more commonly used as a makeshift swear word. People use the word when angry, scared, stressed, etc.
An airhead that brings volume to her hair with loads of hairspray and immense teasing. Consequently, the chemicals from the hairspray become lodged in her brain causing her brain cells to die at an alarming rate. Eventually, this will cause the individual to reach a state of mental retardation. At this point her "poof" becomes a survival mechanism, much like a helmet for her head, in case she runs into doors, walls, windows, etc.