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The state of paranoia in which people fear President Obama so much, they stop thinking logically and stop using common sense. Usually a direct result of watching too much Fox News.
Announcer: This is Skeeter.

Skeeter: Kenyan, Muslim, Communist, Socialist.

Announcer: Skeeter is suffering from Obama Derangement Syndrome.

Skeeter: He bowed to other world leaders. He had a hip-hop barbecue.
by potterfreak98 October 24, 2012
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2
When a person stops disagreeing with Obama on political policy and believe every single policy decision that he make is apart sinister conspiracy to weaken or destroy America and possibly the world.
"Obama will confiscate guns, bring the Muslim brotherhood to power in America, Take all his orders from Putin, declare war on Israel, become a permanent dictator, maybe even become the anti Christ and set up a one world government...But I just disagree with the guy. How an I suffering from Obama Derangement Syndrome?"
by Lexington50 December 02, 2012
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3
The acute onset of paranoia in otherwise normal people in reaction to the policies, the statements -- nay -- the very existence of Barack Obama.
Obama's positions better reflect the change and new direction that the American people have been calling for, but those with Obama Derangement Syndrome would rather stick with failure than even consider voting for him.
by ptulsa May 16, 2008
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