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A word commonly used to express frustration or irritation towards a friend. Usually used in a joking manner and is not intended to be taken seriously. Can also be used in a friendly way to show compassion towards another person.
1. Dude, stop being such a Nippleton.

2. Come on Nippleton, just come with me.
by Danny Donezo February 10, 2010
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Nippleton is an all-female institute of higher education that bends over backwards to please its students and prepare nubile young ladies for the future.
by Mona Licker August 09, 2006
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