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Mittfortune 

To invest a massive amount of your life with a single overriding focus and goal that is all encompassing. To approach realization of this ultimate desire almost totally, to be 99% of the way there - and then to suddenly, entirely, and without question or any chance of ever being able to try again - you lose it... have it all ripped from your hands just as you thought you were about to grasp the grand dream. It's all gone.
For more than 8 solid years Mitt Romney tried and lived only for the purpose of becoming President and moments before he stepped into the Oval Office it was his great mittfortune to be kicked to the curb and left with the trash.
Mittfortune by wdmjr November 8, 2012
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misfortune.gb 

misfortune.gb is an urban legend, a creepypasta, of a game that was made for the original gameboy system. unlike most gameboy games, it was not released on its own cartridge and instead was hidden within other games cartridges and could only be accessed by performing a certain sequence of events or by glitching into the game somehow.

the game consists of level filled with traps and death drops all the while being pursued by a demon that toys with the player characters emotions, and threatening to bring misfortune to any who fail at the game.

players who lost at the game were made to become very depressed, suicidal and even physically sick in some cases and this is what made the story a creepypasta. however, unlike many creepypastas, this was actually true. the hidden game featured a game over screen which showed a picture of the demon that pursues the player and the text "i am god here" written in blood whilst a horrible 8 bit soundtrack played. this music would only play upon losing and the frequencies of the music affected the minds of many people causing these "misfortunes" so to speak, to happen. this can be confirmed with the studies of musicology and psychology.

the game is near impossible to find but it is known to be in at least 5 different gameboy videogame cartridges.
links awakening is a known game to contain misfortune.gb
pokemon red is another.
so is puchi carat.
misfortune.gb by astroboy87 December 6, 2012

misfortune 

bad luck or an unlucky condition or event
Our misfortunes of the last year included the loss of a beloved pet
misfortune by Adrianna Lazaro February 24, 2015

misfortunes never come singly 

this means that bad things or situations always come in groups, they never come in a single way.
A: Guess what?!
B: What?!
A: Last night my car was stolen, anyway, misfortunes never come singly, I lost my wallet today.

Little Misfortune 

A little who deserved a better life but instead got kidnapped by a magic fox, shushes her little butt crack and goes on painful adventures just to find out she was dead the whole time.
Person 1: Have you heard of Little Misfortune?

Person 2: Yeah, she deserved a better life.

misfortune cookie 

Two definitions: (1)a bad piece of news or (2) a batch of cookies that turn out burnt, dry or bad tasting
(1) "I just got a misfortune cookie from my mom - our poodle Rex just died." (2) "Did you taste those misfortune cookies that Camille brought to the picnic? Bleck!"
misfortune cookie by Ambient Guerilla November 19, 2009

musical misfortune 

When you have a song stuck in your head for at least 10 minutes, and right before you get the chance to listen to the song, it finally becomes un-stuck.
john is very annoyed by the 80s song "take on me" that is stuck in his head, so he rushes home, runs up the stairs, opens his laptop, only to realize the song is not stuck in his head anymore.

musical misfortune
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