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originally used in context to video games in which, if a player's character was on the verge of death, one would shout to the player to "man-up." has elvoved into meaning "stop being a big wussy baby."
Dude, stop crying and man-up! (or)

Tony: Dude, can we take a break from the Wii? My hands are cramping?
Ralph: Man-up, wuss!
man-up by SUPER-AWESOME-MAGIC November 30, 2006
v. To act in accordance with established masculine roles in a given situation, implying courage and responsibility. Usually used in the imperative, the term is a favorite of police who want suspects to incriminate themselves. Ironically, advice to 'man-up' is usually followed by a promise that it is the least painful alternative.
You signed for a package full of weed, now you need to man-up, and admit that you knew what was in it. It'll go easier for you with the judge.
man-up by tom ballard, esquire March 2, 2009
adv; mans up, manning up, manned up.

1.To man up: Its time for you to man up for your baby girl.

2.To be manning up: he manned up once he saw the one.

3.To have manned up: he manned up for his son in the past.
1.Did he man-up, or fess-up to his moma!?

2.Today I might be manning-up, for class.
3.Get up to my level of happiness, before you leave.
man-up by RB. 865. January 25, 2014
adv; mans up, manning up, manned up.

1.To man up: Its time for you to man up for your baby girl.
2.To be manning up: he manned up once he saw the one.

3.To have manned up: he manned up for his son in the past.
1.Did he man-up, or fess-up to his moma!?
2.Today I might be manning-up, for class.

3.Get up to my level of happiness, before you leave.
man-up by RB. 865 January 22, 2014
"Hey man, finish this bowl."
"No dude, I'm baked as it is."
"Come on pussy, man up."
Man Up by a dizzle pizzle June 21, 2003
-Verb-

1.) forget about your problem(s) because you were born with a penis, therefore it is not important to anyone that you have any problem(s)

2.) take a risk that you know is against your own interests because someone else thinks you should based on the fact that cannot carry a child to term you disposable motherfucker

3.) be silent and accept your suffering because you have testicles

4.) earn your worth because you don't have a womb and your sperm is dime a dozen.
Examples:

1.) Your wife took your kids, house, is collecting alimony and child support while denying you any access to your children. Why don't you man up, quit being a baby and take the gun out of your mouth? I'm still alive and Iv had to deal with much worse.

2.) Get up soldier! You are here to do a job and it doesn't matter if there are machine gun nests up on that hill! Man up and get up there, thats an order!

3.) I cant believe you cried when your have got smashed in that machine. You should learn to man up like the rest of us.

4.) I don't care how hot it is down in the boiler room. Man up and get back to work you pussy.
Man up by Grievous Scopion August 26, 2013