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1. A herple is a person with herpies. It is a combination or the words "herpes" and "people".

2. A derogatory term or insult, implying that someone has herpes or is otherwise ill or unclean due to promiscuity.

3. A word that rhymes with purple
Oi you fuckin' herple get away from me, we all know where you've been
by Sugar81 July 11, 2010
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