When an object bound to a shelf life, usually food, has past its use by date and is now stale.
Mam? The Milk has gone off.
Ah mank, this bread is moldy as feck. Sure must be gone off.
by Oats Gdankie September 16, 2013
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Short for gone offensive.

When food expires it develops an offensive taste and smell.
Dan: You want some milk Jack?

Jack: No thanks it's gone off and I've not bothered to buy any more.

Dan: I'll go off on you in a minute.
by Words4herds July 1, 2019
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You've gone fucking insane until the point where theres a slim chance of being saved. Your friends usually try and warn you when you have but you're oblivious because you've gone off the deep end.
You: I think I wanna get a tattoo of an infinity sign on my lower back. My girl said it'll look good on me

Me: Dude, you've gone off the deep end.
by Ikcatrac October 18, 2014
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when you love somberly and it’s so easy to go back to them not necessarily meaning you want them
“ i been gone off rock since we broke up
by luvaeod January 13, 2020
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High as hell , on one , euphoric , mixing and matching drugs alcohol, and designer drugs
Is that Quincy ?!?!?! He gone off the bean !!!

Rick is looking weird today !
He gone off da bean
by Dr. Hu September 18, 2019
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