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The act of having an STD and knowingly has sexual intercourse with another man or woman without disclosing this information to them.
Much like when the Europeans came to America, bringing their diseases and wiping out native populations, this act has the potential to cause an STD to spread to multiple people before it was discovered.
I had sex with Mike two months ago, and now I have herpes. I think he did a Dirty Columbus on me. Now my husband Jon has herpes, and he wants to divorce me. Fucking Mike!
by Nutzen YerMouf June 09, 2017
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The act of having anal sex with someone who has never had anal sex before.
It was 2 am and she was a naive girl, drunk and willing try new things, so he suggested the dirty columbus.
by Smedley McScarja November 20, 2013
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