To smoke weed until you're retarded, as Down's Syndrome is cause by the presence of an extra chromosome.
Chich : We finished a quarter ounce between us last night, man. I think I'm still kinda faced.

Chung : Shit son, you don't watch out you'll smoke yourself a spare chromosome.
by Parhelion October 18, 2008
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Used to describe someone who looks as if they possess lower than average intelligence can be male or female of any age – usually found in clapped out Novas around McDonalds car parks and council estates. Can be combined with many other insults -

WARNING – If using insult directly to face – please remember they will not understand the word chromosome – or the word two –

See mouth breather
“Christ! – Look at the mouth breather in the Elisabeth Duke Clown necklace – she looks two chromosomes short of hillbilly
by Andy The Great July 21, 2003
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This is worse than any other insult ever created in mankind. It is worse than ur grandpap a trap and ur family tree lgbt. This wil melt your face and disintegrate you on the spot so you cannot go to hell or heaven and you are trapped in limbo having this said to you for eternity.
Brad: Ur mom gay
Anon: Ur daddy lesbian
Brad:Ur Chromosomes Homo Zones
(Anon fucking dies and turns into dust and gets sent to limbo for the rest of time dying endlessly.)
by Gumpy_Little_Cuck April 18, 2018
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An act by a male that is totally uncalled for. Only males have a Y chromosome and some things they do can be classified as 'typical'
4 guys and a girl walk along the street. she says (looking at her hot dog) 'wow, this is bigger than I thought!'
All guys start laughing and say 'that's what she said'
the girl says 'urgh - you are so y-chromosome-ish!'
by toffeetheturtle17 April 26, 2010
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Basically the equivalent of your not a man anymore.

Used when you see a guy doing something petty like crying or showing their emotions.
Dude did you just cry...? Were gonna have to revoke your Y chromosome.
by JketheSnke69 May 26, 2023
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i have more chromosomes than you: often used to try and roast people but only to realise that it means that you are a trap
Person 1:how many chromosomes do you have
Person 2: i have more chromosomes than you thats for sure
by Bruh sound #3 February 16, 2019
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Conecc chromosomes is a game played by people lacking in chromosomes or people that like to bully people lacking in chromosomes to gain chromosomes off of the other person.
Look I beat that child from Ashley Downs in a game of conecc chromosomes
by Conecc chromosomes May 11, 2020
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