Top definition
To smoke weed until you're retarded, as Down's Syndrome is cause by the presence of an extra chromosome.
Chich : We finished a quarter ounce between us last night, man. I think I'm still kinda faced.

Chung : Shit son, you don't watch out you'll smoke yourself a spare chromosome.
by Parhelion October 18, 2008
Get the mug
Get a smoke yourself a spare chromosome mug for your father-in-law Bob.