Brephew 

A family relation in which someone is a brother and a nephew at the same exact time biologically: when a man has two kids with a mother and a daughter, or when a woman has two kids with a father and son; the brephew being the result of the one person and the younger generation (having the kid with the son or daughter) as related to the bruncle or aunster.

My brephew Chuck is comin' over to visit. Ma' Pa is his Gramps, and we have the same Ma. Yep', livin' in good ole Kentucky sher is fuuunn.

Brephew by fartknocker101 December 22, 2009

Brophew 

Your best friend's son, because saying "my best friend's son" takes forever. A combination of "nephew" and "bro".

Guy: Hey little man, how's my favorite brophew doing?

Brophew: Good, my dad's best friend!

Brophew by Jonathan Caruso December 13, 2010

Brethew 

The cutest fucking guy that you will ever met, and his hair is fucking amazing, and he's smile will make you melt.

You see that Brethew boy? Yeah, he makes this girl named Sam super ass happy.

Brethew by LittleSamIsHappy April 22, 2011