Booty cancer is another way of referring to anal cancer. Anal cancer is a type of cancer that occurs in the anal canal and the anus. It is a rare disease among the general population, but is very common among gay men. Along with that, infections like HIV and Syphilis are also very common among gay men.

Gay men who donโ€™t have HIV are over 20 times more likely to get anal cancer than the general population. Gay men who DO have HIV are about 100 times more likely to get anal cancer. Rates of anal cancer among gay men have been increasing every year.

This is because gay sex often causes anal fissures or tears. The anus is supposed to remove waste from the body, and having gay sex will eventually cause tears and cuts to the anus. These tears can get infected.
Infections and diseases like HIV, AIDS, Syphilis, and anal cancer (or booty cancer) are very common among gay men. This is a simple fact.
by Medical School October 21, 2019
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A word used to describe a girl's gluteus maximus that has an oddly shape to it and usually possesses strange lumps, bumps, dipples, crevices and right angles. This type of asymmetric and disproportioned ass is almost always seen as unattractive to an onlooker.
Male 1: Hey, did you see Sam in her new corteroid pants?

Male 2: Unfortunately yes, her ass appeared like it had booty cancer, I nearly threw up.
by EmceeOnslaught December 15, 2009
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1. describe an event that didn't go as planned or badly.

2. cancer of the ass.
1. -my dad yelled at me for being sick.

-wtf that's booty cancer. :(

2.doctor- the tests came back positive for booty cancer.
by Infernal Isolation March 5, 2009
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