Abnosome Share definition Flag A new word created in 2013 by CW actor Misha Collins during the annual Greatest Internation Scavenger Hunt the World Has Ever Seen (GISHWHES), with the meaning:'Awesome in an abnormal way' Speaker one: "I cut off all my hair and wore underwear made of Toast for G.I.S.H.W.H.E.S!" Speaker two: "That is so abnosome!" Abnosome by juxtai August 20, 2013 Get the Abnosome mug.