Sis

A sexual nickname between gang members.

Hey there sis.

by Gang guy 254 January 29, 2016

Sis

The ultimate friendzone

Short for sisters

1- hey

2-hey sis

by Mandagrace99 November 24, 2018

sis

The Queen Bitch Hacker

"Sis & Sabbath Own you"

by Sis March 8, 2003

Sis

A word basic bitches use to get a point across.
It’s the most cringe worthy word that can be used and should be illegal in every way.

“Omg sis I just got a brand new Rolex”
“Sis hop in my fiat500 let’s go for a ride”

by Shanosthetranos July 7, 2020

Sis

A sexual nickname used by gang members

Hey sis

by Gang guy 254 January 29, 2016

SI

Level Trim for Honda Civic and etc... it means.. SLOW IMPORT..

That SI got beat by my geo.

by HawkINX4 April 14, 2004

Sis

A perfect response to your friend saying something stupid, bitchy, slutty or just something u can't think of a reply to

Person 1: Idk which guy to meet this weekend, there's a choice of 3
Person 2: sis

by Theteakeeper January 12, 2019